ENCODE - Encyclopedia of DNA Elements released

A long-term effort to catalogue all the bits of the human genome that do something has released its results. The consortium that created this—442 members in 32 institutes around the world—has used the increasingly impressive tools available for sequencing genomes to mount a systematic analysis of 147 different types of human cell, attempting to say just what each part of the genome is doing in them. Their results confirm on a grand scale what has become clear over the decade since the Human Genome Project first produced a sequence of the three billion “letters” of which the genome is made: there is a great deal more to genomes than their genes. Impressive as it is, ENCODE is far from the last word. For one thing, its expertise and carefully calibrated techniques need to be spread far and wide—to be adopted and made useful by people doing clinical research. And there is more basic research to do. Only six of the 147 cell types looked at in ENCODE were studied in the amount of detail now possible. The others still await their close-up. So far ENCODE has looked only at cells from one person for each of the cell types studied. That is a reasonable simplification; in terms of how the genome works, the difference between what’s turned on and off in a liver cell and a skin cell is far greater than the difference between how one person’s skin cells work and those of their neighbour, however genetically different the neighbour. But it will be helpful to get a sense of differences between your liver cells and your neighbour’s—especially if you are ill and he is healthy. But ... ENCODE has definitely surpassed the original genome-sequencing efforts !!! Courtesy: The Economist